Overview

Maturity-onset diabetes of the young (MODY) is a group of inherited disorders of non-autoimmune diabetes mellitus which usually present in adolescence or young adulthood. Up to 5% of all diabetes cases may be due to MODY. Any of several hereditary forms of diabetes mellitus brought on by mutations in an autosomal dominant gene that impair insulin production are referred to as maturity-onset diabetes of the young (MODY). MODY is one of the conditions known as monogenic diabetes along with neonatal diabetes. All forms of MODY are caused by changes to a single gene (monogenic) whereas the more common types of diabetes (especially type 1 and type 2) involve more complex combinations of causes involving multiple genes and environmental factors.

Causes

MODY is caused by a change or mutation in one of your genes. This is distinct from type 1 and type 2 diabetes which are caused by a combination of genes and other factors such as obesity. MODY causes a genetic change that prevents your pancreas from producing enough insulin a hormone that regulates blood sugar levels.

Symptoms

The symptoms of MODY vary depending on which of your genes is affected. Some people may not experience any symptoms at all. However, the disease typically manifests itself gradually. You could have high blood sugar for years before noticing any of these warning signs: 

• Thirsty or hungry more frequently 

• Peeing

• Blurry vision

• Skin or yeast infections 

• Weight loss 

• Fatigue

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